Oxymorphone (By mouth)
Treats moderate to severe pain. This medicine is a narcotic pain reliever.
Opana ER, OpanaThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:You should not use this medicine if you have had an allergic reaction to oxymorphone, morphine, codeine, or other narcotic pain medicines. You should not use this medicine during an asthma attack, or if you have severe asthma, trouble breathing, or liver disease. You should not use the extended-release tablet if you have a condition called paralytic ileus (blockage of the bowel), or if you need pain medicine for just a short time, such as when recovering from surgery.
How to Use This Medicine:
Tablet, Long Acting Tablet
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- It is best to take this medicine on an empty stomach, at least one hour before or two hours after a meal.
- Swallow the extended-release tablet whole. Do not crush, break, or chew it.
- Drink plenty of fluids to help avoid constipation.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Flush all leftover medicine down the toilet after you have finished your treatment. Also flush old medicine after the expiration date has passed. This medicine is one of only a few medicines that should be disposed of this way.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are using other narcotic pain relievers (such as buprenorphine, butorphanol, nalbuphine, pentazocine, Buprenex®, Nubain®, Stadol®, Talwin®), phenothiazine medicine (such as prochlorperazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, Trilafon®), an MAO inhibitor such as (Eldepryl®, Marplan®, Nardil®, Parnate®), or a stomach medicine (such as cimetidine, Tagamet®).
- Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.
- Do not drink alcohol while you are using this medicine.
Warnings While Using This Medicine:
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have seizures, low blood pressure, heart disease, kidney disease, thyroid problems, pancreas problems, Addison's disease, an enlarged prostate, problems passing urine, or a history of drug or alcohol abuse or addiction. Tell your doctor if you have lung disease (such as asthma or chronic obstructive pulmonary disease) or other conditions that may cause breathing problems, such as sleep apnea (breathing stops during sleep), scoliosis (an abnormal spine curve), severe obesity, depression, brain disease, or recent head injury.
- This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with general anesthesia (sleeping medicine) and other medicines used during surgery and certain procedures.
- Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.
- This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert. You may also feel lightheaded when standing suddenly from a sitting or lying position, so get up slowly.
- This medicine may cause constipation. This is more common if you use it for a long time. Ask your doctor if you should also use a laxative to prevent and treat constipation.
- Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.
- If your symptoms do not improve or if they get worse, call your doctor.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Confusion, mood or mental changes, or depression.
- Decrease in how much or how often you urinate.
- Irregular, fast, slow, or shallow breathing.
- Lightheadedness or fainting.
- Severe constipation or stomach pain.
- Shortness of breath.
If you notice these less serious side effects, talk with your doctor:
- Decreased appetite.
- Dry mouth.
- Increased sweating.
- Mild constipation, diarrhea, nausea, or vomiting.
- Sleepiness or trouble sleeping.
- Tiredness or weakness.
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
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