Lisinopril/hydrochlorothiazide (By mouth)
Hydrochlorothiazide (hye-droe-klor-oh-THYE-a-zide), Lisinopril (lye-SIN-oh-pril)
Treats high blood pressure. Lowering blood pressure reduces the risk of strokes and heart attacks. This medicine is a combination of an angiotensin-converting enzyme (ACE) inhibitor and a diuretic ("water pill").
Prinzide, ZestoreticThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:You should not use this medicine if you have had an allergic reaction to lisinopril, hydrochlorothiazide, sulfa drugs (such as sulfamethoxazole/trimethoprim, sulfasalazine, sulfisoxazole, Azulfidine®, Bactrim®, Gantrisin®, or Septra®), or certain blood pressure medicines (such as Accupril®, Altace®, Lotensin®, Lotrel®, Monopril®, or Zestoretic®). You should not use this medicine if you are pregnant, or if you have hereditary or idiopathic angioedema or are not able to form urine (anuria).
How to Use This Medicine:
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- This medicine should not be the first medicine you use to treat your condition. It is meant to be used only after you have tried other medicines that have not worked or have caused unwanted side effects.
- You may take this medicine with or without food.
- Carefully follow your doctor's instructions about any special diet. Be sure to drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are using lithium (Eskalith®, Lithobid®), gold injections (such as sodium aurothiomalate), or a diuretic or "water pill" (such as amiloride, chlorthalidone, eplerenone, furosemide, spironolactone, triamterene, Aldactazide®, Aldactone®, Inspra®, Dyazide®, Dyrenium®, Lasix®, Maxzide®, Midamor®, Moduretic®, or Thalitone®). Your doctor will need to know if you are using insulin or a diabetes medicine that you take by mouth (such as glipizide, glyburide, metformin, Actos®, Amaryl®, Avandia®, Glucotrol®, or Glucophage®) or a steroid medicine (such as dexamethasone, prednisolone, prednisone, or Medrol®).
- Tell your doctor if you are using sleeping pills (such as lorazepam, Ativan®), narcotic pain relievers (such as acetaminophen/codeine, acetaminophen/oxycodone, acetaminophen/hydrocodone, Endocet®, Lorcet®, Percocet®, or Vicodin®), or a pain or arthritis medicine (such as aspirin, celecoxib, diclofenac, ibuprofen, naproxen, piroxicam, rofecoxib, valdecoxib, Advil®, Aleve®, Bextra®, Celebrex®, Feldene®, Motrin®, Vioxx®, or Voltaren®). Make sure your doctor knows if you are using norepinephrine, tubocurarine, or a medicine to lower your cholesterol (such as cholestyramine, colestipol, Colestid®, or Questran®).
- Do not use medicines, supplements, or salt substitutes that contain potassium without checking first with your doctor.
- Drinking alcohol or taking narcotic pain relievers or sleeping pills with this medicine may intensify feeling lightheaded, dizzy, or faint. Tell your doctor if you are drinking alcohol or using pain relievers or sleeping pills.
Warnings While Using This Medicine:
- Using this medicine while you are pregnant (especially in your second or third trimester) can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.
- Make sure your doctor knows if you are breastfeeding, or if you have kidney problems, liver disease, congestive heart failure, dehydration, edema or body swelling, heart or blood vessel disease, heart valve problems, low blood pressure, low blood volume, high cholesterol or fats in the blood, or mineral imbalance (such as high or low calcium, magnesium, potassium, or sodium in the blood). Tell your doctor if you have diabetes, glaucoma, gout, lupus, an autoimmune disorder (such as collagen vascular disease), or a history of asthma or airway surgery.
- This medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life.
- This medicine may cause serious types of allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.
- Tell your doctor about any allergic reaction you have had to any drug, especially if the reaction caused you to have swelling in your face, lips, tongue, or throat.
- Stop using this medicine and call your doctor right away if you have severe stomach pain (with or without nausea or vomiting). This could be a symptom of a condition called intestinal angioedema.
- This medicine may make you dizzy or lightheaded. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert. Dizziness may be worse if you lose too much water from your body. You can lose water by sweating, having diarrhea, or vomiting. Tell your doctor if this medicine makes you feel lightheaded or dizzy after you have been vomiting or had diarrhea.
- Stop using this medicine and check with your doctor right away if you have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.
- This medicine may raise your blood sugar. You should check your blood sugar more often during the first month you take this medicine, and then on a regular basis.
- Check with your doctor if you notice any signs of fever, chills, or sore throat. These could be symptoms of an infection resulting from low white blood cell counts.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
- This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
- Check with your doctor immediately if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).
- Black patients may be less sensitive to the blood pressure-lowering effects of this medicine. In addition, the risk of a serious allergic reaction involving swelling of the face, mouth, hands, or feet may be increased.
- If you stop using this medicine, your blood pressure may go up. High blood pressure usually has no symptoms. Even if you feel well, do not stop using the medicine without asking your doctor.
- Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments. Blood and urine tests may be needed to check for unwanted effects.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, or red skin rash.
- Blurred vision, or changes in vision.
- Change in how much or how often you urinate, or problems urinating.
- Chest pain.
- Confusion, body weakness, uneven heartbeat, shortness of breath, or numbness or tingling in your hands, feet, or lips.
- Dark-colored urine or pale stools.
- Dry mouth, increased thirst, or muscle cramps.
- Fast, slow, or pounding heartbeat.
- Fever, chills, runny or stuffy nose, sore throat, and body aches.
- Increased shakiness or hunger.
- Lightheadedness, dizziness, or fainting.
- Nausea, vomiting, loss of appetite, or stomach pain.
- Rapid weight gain.
- Severe stomach pain.
- Swelling in your hands, ankles, or feet.
- Unusual bleeding, bruising, or weakness.
- Unusual tiredness or weakness.
- Yellowing of your skin or the whites of your eyes.
If you notice these less serious side effects, talk with your doctor:
- Dry cough.
- Mild skin rash or itching.
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
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