Tacrolimus (By mouth)
Keeps your body from rejecting an organ transplant such as a kidney, liver, or heart. This medicine is always used together with steroids, azathioprine (Imuran®), or mycophenolate mofetil (Cellcept®).
Prograf, Novaplus TacrolimusThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:You should not use this medicine if you have had an allergic reaction to tacrolimus.
How to Use This Medicine:
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- You may take this medicine with or without food. You should take it the same way each time.
- This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
- This medicine is always used together with other medicines. Make sure you understand when to take all of your medicines during the day. Your doctor will give you a daily plan for taking your medicines.
- Do not stop taking this medicine without first checking with your doctor. You might have to take medicine for the rest of your life to prevent your body from rejecting the transplant.
If a dose is missed:
- This medicine needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.
How to Store and Dispose of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are using cisplatin (Platinol®-AQ), cyclosporine (Gengraf®, Neoral®, or Sandimmune®), or sirolimus (Rapamune®). Tell your doctor if you are also using medicine for high blood pressure (such as candesartan, diltiazem, enalapril, lisinopril, losartan, nicardipine, nifedipine, verapamil, Accupril®, Atacand®, Avapro®, Calan®, Capoten®, Cardene®, Cartia®, Cozaar®, Lotrel®, Procardia®, or Zestril®) or stomach problems (such as antacids, cimetidine, lansoprazole, metoclopramide, omeprazole, Mylanta®, Prevacid®, Prilosec®, Reglan®, or Tagamet®).
- Make sure your doctor knows if you are using bromocriptine (Parlodel®), danazol (Danocrine®), ethinyl estradiol (Estinyl®), methylprednisolone (Medrol®), nefazodone (Serzone®), or St. John's wort. Your doctor should also know if you are using medicines to treat seizures (such as carbamazepine, phenobarbital, phenytoin, Carbatrol®, Dilantin®, or Tegretol®) or diuretics ("water pills") such as spironolactone, triamterene, Aldactone®, Dyazide®, or Dyrenium®.
- Tell your doctor if you are using medicines to treat bacterial infections (such as amikacin, chloramphenicol, clarithromycin, erythromycin, gentamicin, rifabutin, rifampin, streptomycin, troleandomycin, Amikin®, Biaxin®, Ery-Tab®, Garamycin®, Mycobutin®, Rifadin®, or Tao®), virus infections (such as ganciclovir, indinavir, nelfinavir, ritonavir, tenofovir, Cytovene®, Norvir®, Viracept®, or Viread®), or fungus infections (such as amphotericin B, caspofungin, clotrimazole, fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole, Amphocin®, Cancidas®, Clotrim®, Diflucan®, Nizoral®, Noxafil®, Sporanox®, or Vfend®).
- Talk to your doctor before getting flu shots or other vaccines while you are receiving this medicine. Vaccines may not work as well, or they could make you ill while you are using this medicine.
- Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine:
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, paresthesias (numbness or tingling in the hands, arms, legs, or feet), diabetes, myocardial hypertrophy (the heart is larger than normal), high blood pressure, high potassium in the blood, or any type of infection.
- This medicine may increase your risk of getting skin cancer or cancer of the lymph system (lymphoma). Talk to your doctor if you have concerns about this risk.
- This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
- This medicine may increase your risk of developing infections. Avoid being near people who are sick while you are using this medicine. Wash your hands often. Tell your doctor if you have any kind of infection before you start using this medicine. Also tell your doctor if you have ever had an infection that would not go away or an infection that kept coming back.
- This medicine may increase your risk for developing a rare and serious virus infection with the BK polyoma virus. This virus may affect how your kidneys work and cause a transplanted kidney to fail. Check with your doctor right away if you are having more than one of these symptoms: bloody urine; a decreased frequency or amount of urine; increased thirst; loss of appetite; lower back or side pain; nausea; swelling of the face, fingers, or lower legs; trouble with breathing; unusual tiredness or weakness; vomiting; or weight gain.
- This medicine may increase your risk of developing a serious and rare brain infection called progressive multifocal leukoencephalopathy (PML). Check with your doctor right away if you are having more than one of these symptoms: vision changes, loss of coordination, clumsiness, confusion, memory loss, difficulty speaking or understanding what others say, and weakness in the legs.
- This medicine may cause serious nervous system problems. Tell your doctor right away if you have the following symptoms while using this medicine: blurred vision, dizziness, headache, mental changes, seizures, high blood pressure, or a fast heartbeat.
- Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have the following symptoms: abdominal or stomach pain; confusion; difficulty with breathing; an irregular heartbeat; nausea or vomiting; nervousness; numbness or tingling in the hands, feet, or lips; shortness of breath; or weakness or heaviness of the legs.
- This medicine may cause a condition called pure red cell aplasia (PRCA). This is a very rare condition where the body no longer makes red blood cells and the patient has severe anemia. Check with your doctor right away if you have a fever and sore throat; pale skin; unusual bleeding or bruising; or unusual tiredness or weakness.
- Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, or red skin rash.
- Blood in the urine, lower back pain, side pain, or sharp back pain just below the ribs.
- Change in how much or how often you urinate, or painful urination.
- Chest pain, shortness of breath, cold sweat, and bluish-colored skin.
- Confusion, body weakness, uneven heartbeat, or numbness or tingling in your hands, feet, or lips.
- Dark-colored urine or pale stools.
- Dry mouth, muscle cramps, nausea, or vomiting.
- Fast, slow, or pounding heartbeat.
- Fever, chills, cough, sore throat, and body aches.
- Gaining weight around your neck, upper back, breast, face, or waist.
- Increased thirst or hunger.
- Lightheadedness, dizziness, or fainting.
- Numbness or weakness in your arm or leg, or on one side of your body.
- Problems with hearing, vision, speech, balance, or walking.
- Rapid weight gain.
- Seeing or hearing things that are not really there.
- Seizures, tremors, or muscle twitching.
- Sudden and severe stomach pain.
- Swelling in your hands, ankles, or feet.
- Trouble breathing or swallowing.
- Unusual bleeding, bruising, or weakness.
- Yellowing of your skin or the whites of your eyes.
If you notice these less serious side effects, talk with your doctor:
- Agitation, depression, nervousness, or mood changes.
- Diarrhea, constipation, loss of appetite, or upset stomach.
- Hair loss, or increased body hair.
- Joint pain or back pain.
- Mild skin rash.
- Sores or white patches on your lips, mouth, or throat.
- Trouble sleeping.
- Warmth or redness in your face, neck, arms, or upper chest.
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
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