Conjugated estrogens (Vaginal)
Conjugated Estrogens (KON-joo-gay-ted ES-troe-jenz)
Treats vaginal dryness, itching, and burning caused by low estrogen levels or menopause. Also treats vaginal pain during sexual intercourse.
Premarin VaginalThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:You should not use this medicine if you have had an allergic reaction to estrogens, or if you may be pregnant. Do not use this medicine if you have liver disease or certain kinds of cancer (such as breast cancer). You should not use this medicine if you have had a heart attack, stroke, or a problem with blood clots (such as a deep vein thrombosis [DVT] or a lung embolism). Do not use this medicine if you have unusual vaginal bleeding that has not been checked by a doctor.
How to Use This Medicine:
- Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
- This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
- Wash your hands with soap and water before and after using this medicine.
- This medicine is to be used only in the vagina. Use at bedtime unless your doctor tells you otherwise.
- Wash the applicator with warm, soapy water after you use it. If the medicine comes with disposable applicators, use each applicator only once, and then throw it away.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of the used medicine applicator(s), containers and any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using carbamazepine (Tegretol®), clarithromycin (Biaxin®), erythromycin (Ery-Tab®), itraconazole (Sporanox®), ketoconazole (Nizoral®), phenobarbital (Luminal®), rifampin (Rifadin®, Rimactane®), ritonavir (Norvir®), St. John's wort, or a blood thinner such as warfarin (Coumadin®).
- Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
- Avoid using douches or other vaginal products unless your doctor tells you to.
Warnings While Using This Medicine:
- Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. This medicine may cause latex or rubber condoms, diaphragms, or cervical caps to break. If you think you have become pregnant while using the medicine, tell your doctor right away.
- Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, heart disease, liver disease, gallbladder problems, high blood pressure, cancer, asthma, epilepsy, migraine headaches, diabetes, endometriosis (uterus problem), tumors in your uterus (womb), bone disease, depression, lupus, porphyria (an enzyme problem), thyroid problems, high calcium in the blood, vision problems, history of liver problems caused by estrogen use or during pregnancy, or a family history of breast cancer or high cholesterol in the blood.
- Your doctor will need to check your progress at regular visits while you are using this medicine (usually 6 months to 1 year). Be sure to keep all appointments.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine before you have surgery or if you need to stay in bed for an extended time. This medicine may affect the results of certain medical tests.
- Using large amounts of this medicine over long periods of time may increase your risk of some kinds of cancer. Talk to your doctor about your personal risks compared with the benefits of this medicine.
- Using this medicine may increase your risk for having blood clots, strokes, or heart attacks. This risk may continue even after you stop using the medicine. Your risk for these serious problems is even greater if you have high blood pressure, high cholesterol in your blood, or diabetes. Your risk is also greater if you are overweight or smoke cigarettes. Talk to your doctor about your personal risks compared with the benefits of this medicine.
- This medicine may increase the risk for having dementia (loss of some mental abilities, such as memory or judgment) in women over 65 years old. Talk with your doctor about this risk.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Breast lumps (in women or men).
- Chest pain, shortness of breath, or coughing up blood.
- Confusion or memory problems.
- Fever, chills, cough, sore throat, and body aches.
- Numbness or weakness in your arm or leg, or on one side of your body.
- Pain in your lower leg (calf).
- Problems with vision, speech, or walking.
- Rapid weight gain.
- Sudden or severe headache.
- Swelling in your hands, ankles, or feet.
- Unusual vaginal bleeding or discharge.
- Yellowing of your skin or the whites of your eyes.
If you notice these less serious side effects, talk with your doctor:
- Back or joint pain.
- Breast pain or tenderness.
- Hair loss.
- Increased vaginal itching.
- Mild headache or dizziness.
- Mild nausea, vomiting, diarrhea, bloating, or stomach cramps or pain.
- Stuffy or runny nose.
- Trouble sleeping.
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
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